IL-10 and TNF-α promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan

Clinical and Experimental Rheumatology

Ying-Ju Lin¹  S-Y Chen¹  D-Y Chen¹  K-C Hsueh¹  C-C Lai¹  C-M Huang¹  F-J Tsai¹  T-H Lin¹  J J-C Sheu¹  Lei Wan¹ 

关键词: Systemic lupus erythematosus;    interleukin-10;    tumour necrosis factor-α;    single nucleotide polymorphism;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES: The genetic control of Interleukin-10 (IL-10) and Tumour necrosis factor-α (TNF-α) production and the possible interaction between the two cytokines in influencing SLE susceptibility as well as clinical features has not been completely evaluated in the Taiwanese population. METHODS: We investigated the association of IL-10 and TNF-α promoter polymorphisms (-1082, -819 and -592 for IL-10 gene; -308 for TNF-α gene) with SLE in a total of 172 Taiwanese patients and 215 controls. RESULTS: Our results indicate that IL-10 A/T/A-A/T/A genotype was associated with Taiwanese SLE, whereas no significance was observed between TNF-αgenotype and SLE. Furthermore, the TNF-α G allele frequency of the polymorphism at -308 was significantly decreased in patients with oral ulcers. The combined frequencies of IL-10 A/T/A haplotype and TNF-α G-G genotype were significantly increased in SLE patients. In addition, the combined frequencies of IL-10 A/T/A haplotype and TNF-α G-G genotype were significantly decreased in patients with oral ulcers. CONCLUSIONS: These results suggest a significant correlation of the combined IL-10 and TNF-α genetic polymorphisms contribute to SLE susceptibility and clinical features in the Taiwanese population.

【 授权许可】

Unknown