Assessment of disease activity in rheumatoid arthritis using a novel folate targeted radiopharmaceutical FolatescanTM

Clinical and Experimental Rheumatology

V.J. Lowe¹  C.S. Crowson¹  K.G. Moder¹  R.A. Messmann¹  E.L. Matteson¹  P.S. Low¹  D.E. Morgenstern¹  F.G. Prendergast¹ 

关键词: Folate receptor;    FolateScan;    rheumatoid arthritis;    radiopharmaceutical.;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES:Development of a simple and accurate technique for detecting active inflammation in the joints and other tissues of patients with inflammatory disorders is an unmet need in rheumatic diseases. This study is a preliminary assessment of the safety and usage of a radiopharmaceutical, FolateScanTM (Technetium-99m EC20; 99mTc-EC20), for detecting disease activity in patients with rheumatoid arthritis.METHODS:EC20 is a folate-targeted diagnostic radiopharmaceutical which binds to the folate receptor and is preferentially taken up by activated macrophages. In this open-label, cross-sectional study, a total of 40 patients with RA (26 with one or more swollen joints, 14 with clinically quiescent joint disease; 0/66 joint count) as well as 6 patients with osteoarthritis, 12 patients with other inflammatory conditions and 5 healthy subjects received 0.1 mg of EC20 labeled with 20-25mCi of technetium-99m. Disease activity was scored in each joint and other target tissues by a radiologist blinded to the clinical assessment, and results were compared to the rheumatologist`s physical examination, which served as the test standard. RESULTS:The 40 patients (78% female) with RA had a mean age of 56.9 years. Assessment of uptake of 99mTc-EC20 in joints of patients with RA based on image analysis was compared to the clinical examination. FolateScan detected more actively involved joints in 27 patients (68%) than joints recorded as `swollen`, and more actively involved joints in 25 patients (63%) than joints recorded as `painful and/or swollen`. The number of swollen joints by clinical exam was correlated with ESR (r=0.43; p=0.006) and C-rp (r=0.35; p=0.03). The number of actively involved joints by FolateScan was also correlated with ESR (r=0.47; p=0.002) and C-rp (r=0.36; p=0.02). Joint uptake was also seen in patients with osteoarthritis. CONCLUSIONS:FolateScan is a potentially useful tool for detection of disease activity in patients with RA and may be more sensitive than the physical examination.

【 授权许可】

Unknown