Association of MICA alleles with psoriatic arthritis and its clinical forms. A multicenter Italian study

Clinical and Experimental Rheumatology

V. Fanni¹  C. Carcassi¹  F. Iannone¹  E. Taccari¹  A. Cauli¹  R. Ramonda¹  A. Spadaro¹  L. Punzi¹  A. Vacca¹  G. Lapadula¹  A. Mathieu¹  A. Mameli¹  M.T. Fiorillo¹  R. Peluso¹  R. Scarpa¹  G. Passiu¹  R. Sorrentino¹ 

关键词: MICA gene polymorphisms;    extended haplotypes;    psoriatic arthritis.;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

OBJECTIVES:Analysis of the association between psoriatic arthritis (PsA) clinical forms and MICA gene transmembrane polymorphisms.METHODS:Patients were classified as having peripheral asymmetric oligoarthritis (AO), peripheral symmetric poly-arthritis (PA) and spondylitis (SP), or disease combinations (PA/SP, OA/SP). Two hundred and twenty-six patients with PsA were typed for MICA exon 5 microsatellite (TM) by heteroduplex analysis and compared with 225 normal controls. RESULTS:MICA-TM microsatellite typing revealed that, among the different clinical forms of PsA, only the combined PA/SP subset shows a significant positive association with MICA-A9 and a lower frequency of MICA-A4, A5 genotype in PsA patients with a decrease, only in the PA/SP cohort, of all MICA-A5 combinations except MICA-A5, -A9.CONCLUSIONS:These results suggest a role for genes within the HLA region in the pathogenesis of PsA, and reinforce the idea that the different forms of PsA may have heterogeneous genetic basis.

【 授权许可】

Unknown