A case of Brucella spondylitis in a patient with psoriatic arthritis receiving infliximab.

Clinical and Experimental Rheumatology

I. Vrabie¹  A.K. Zikou1¹  P.V. Voulgari¹  A.A. Drosos¹  M.I. Argyropoulou¹  C.E. Papagoras¹ 

关键词: Brucella spondylitis;    anti-TNFα agents;    infliximab;    psoriatic arthritis.;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

ABSTRACT:A 69-year-old woman with psoriatic arthritis treated with infliximab presented with low back pain of recent onset and fever. Serological, microbiological and imaging studies revealed Brucella spondylitis at the L5-S1 level. Immunosuppressive therapy was suspended and antibiotic therapy including doxycycline and rifampicin was administered for six months. The patient responded adequately with clinical and laboratory improvement and a considerable remission of spondylitis on repeat magnetic resonance imaging scan. The pathophysiology of tumor necrosis factor (TNF) α in Brucellosis and the role of anti-TNFα therapy are discussed.

【 授权许可】

Unknown