The islet‐specific glucose‐6‐phosphatase‐related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane

FEBS Letters

Shieh, Jeng-Jer¹  Mansfield, Brian C.¹  Pan, Chi-Jiunn¹  Chou, Janice Yang¹ 

[1] Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, Building 10, Room 9S241, National Institutes of Health, Bethesda, MD 20892-1830, USA

关键词: Glucose-6-phosphatase;    Diabetes mellitus;    Membrane topography;    Endoplasmic reticulum;    Proteasome;    Transmembrane domain;    IGRP;    islet-specific glucose-6-phosphatase-related protein;    G6Pase;    glucose-6-phosphatase;    G6P;    glucose-6-phosphate;    ER;    endoplasmic reticulum;    MHC;    major histocompatibility complex;   

DOI  :  10.1016/S0014-5793(04)00223-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The islet-specific glucose-6-phosphatase-related protein (IGRP) has no known catalytic activity, but is of interest because it is the source of the peptide autoantigen targeted by a prevalent population of pathogenic CD8⁺ T cells in non-obese diabetic mice. To better understand the potential roles of this protein in diabetes mellitus, we examine the subcellular localization and membrane topography of human IGRP. We show that IGRP is a glycoprotein, held in the endoplasmic reticulum by nine transmembrane domains, which is degraded in cells predominantly through the proteasome pathway that generates the major histocompatibility complex class I-presented peptides.

【 授权许可】

Unknown