RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

FEBS Letters

Lee, Jae Yung²  Kim, Joon¹  Jang, Chang-Young¹ 

[1] Laboratory of Biochemistry, School of Life Sciences & Biotechnology, and BioInstitute, Korea University, Seoul 136-701, South Korea;Department of Biology, Mokpo National University, Muan, Chonnam 534-729, South Korea

关键词: rpS3;    DNA repair;    Apoptosis;    Cytokine;    Lymphocyte;   

DOI  :  10.1016/S0014-5793(04)00074-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.

【 授权许可】

Unknown