Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation

FEBS Letters

Hoeks, Joris¹  Hesselink, Matthijs K.C²  Schaart, Gert²  Saris, Wim H.M¹  Schrauwen, Patrick¹  van Bilsen, Marc³  van der Vusse, Ger J³ 

[1] Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands;Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands;Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands

关键词: UCP3;    Thermogenesis;    Medium chain triacylglycerol;    Mitochondrion;    High-fat diet;    Peroxisome proliferator-activated receptor;    Lipotoxicity;   

DOI  :  10.1016/S0014-5793(03)01343-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain – but not medium chain – fatty acid supply upregulates UCP3 in all muscles. Since plasma non-esterified fatty acids and the expression of two peroxisome proliferator-activated receptor (PPAR)-responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR-mediated. This study supports a role of UCP3 in export of non-metabolizable fatty acids.

【 授权许可】

Unknown