Relationship between intramolecular hydrogen bonding and solvent accessibility of side‐chain donors and acceptors in proteins

FEBS Letters

Brazhnikov, Evgenii V¹  Efimov, Alexander V¹ 

[1] Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

关键词: Hydrogen bond;    Intramolecular interaction;    Protein database analysis;    Stability;   

DOI  :  10.1016/S0014-5793(03)01189-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This study shows that intramolecular hydrogen bonding in proteins depends on the accessibility of donors and acceptors to water molecules. The frequency of occurrence of H-bonded side chains in proteins is inversely proportional to the solvent accessibility of their donors and acceptors. Estimates of the notional free energy of hydrogen bonding suggest that intramolecular hydrogen-bonding interactions of buried and half-buried donors and acceptors can contribute favorably to the stability of a protein, whereas those of solvent-exposed polar atoms become less favorable or unfavorable.

【 授权许可】

Unknown