Is there an evolutionary relationship between WARP (von Willebrand factor A‐domain‐related protein) and the FACIT and FACIT‐like collagens?

FEBS Letters

Fitzgerald, Jamie¹  Bateman, John F.¹ 

[1] Cell and Matrix Biology Research Unit, Murdoch Childrens Research Institute, and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Vic. 3052, Australia

关键词: Von Willebrand factor A-domain;    Fibril-associated collagen with interrupted triple helix;    Collagen evolution;    Genome duplication;    Extracellular matrix;    WARP;    von Willebrand factor A-domain-related protein;    FACIT;    fibril-associated collagen with interrupted triple helix;    VWFA;    von Willebrand factor A;    FN3;    fibronectin type III;    ECM;    extracellular matrix;   

DOI  :  10.1016/S0014-5793(03)00968-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We suggest that there is an evolutionary relationship between von Willebrand factor A-domain-related protein (WARP), and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens. Data from a comparison of amino acid sequences, domain organisation and chromosomal location are consistent with the hypothesis that WARP and these collagens share a common collagen ancestor. In support of this is the observation that the WARP 3′ coding region is GC-rich suggesting that this may represent the remnant of a triple helix protein domain which WARP has ‘lost’ during evolution.

【 授权许可】

Unknown