WARP is a new member of the von Willebrand factor A‐domain superfamily of extracellular matrix proteins

FEBS Letters

Fitzgerald, Jamie¹  Tay Ting, Su¹  Bateman, John F.¹ 

[1] Cell and Matrix Biology Research Unit, Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Vic. 3052, Australia

关键词: Von Willebrand factor A-domain;    Fibronectin type III repeat;    Extracellular matrix;    WARP;    von Willebrand factor A-domain-related protein;    VA-domain;    von Willebrand factor A-domain;    F3;    fibronectin type III repeat;    ECM;    extracellular matrix;    EST;    expressed sequence tag;    RT-PCR;    reverse transcription-polymerase chain reaction;    SDS–PAGE;    sodium dodecyl sulphate–polyacrylamide gel electrophoresis;   

DOI  :  10.1016/S0014-5793(02)02579-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We report a new member of the von illebrand factor A-domain protein superfamily, WARP (for von illebrand factor -domain-elated rotein). The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repeats, and a short proline- and arginine-rich segment. WARP mRNA was expressed predominantly in chondrocytes and in vitro expression experiments in transfected 293 cells indicated that WARP is a secreted glycoprotein that forms disulphide-bonded oligomers. We conclude that WARP is a new member of the von Willebrand factor A-domain (VA-domain) superfamily of extracellular matrix proteins which may play a role in cartilage structure and function.

【 授权许可】

Unknown