Membrane traffic fuses with cartilage development

FEBS Letters

Sacher, Michael¹ 

[1] Biotechnology Research Institute, 6100 Royalmount Avenue, Montreal, QC, Canada H4P 2R2

关键词: Membrane traffic;    Spondyloepiphyseal dysplasia tarda;    Transport protein particle;    Sedlin;    ER;    endoplasmic reticulum;    MBP-1;    c-myc promoter binding protein-1;    SEDL;    spondyloepiphyseal dysplasia tarda;    TRAPP;    transport protein particle;   

DOI  :  10.1016/S0014-5793(03)00854-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ability of cells to synthesize and secrete proteins is essential for numerous cellular functions. Therefore, when mutations in one component of the secretory pathway result in a tissue-specific defect, a unique opportunity arises to examine the molecular mechanisms at play. The recent finding that a defect in the protein sedlin, whose yeast counterpart is involved in the first step of the secretory pathway, leads to a cartilage-specific disorder in humans raises numerous questions and interesting possibilities for understanding both the pathobiology involved and the role of membrane traffic in normal cartilage development.

【 授权许可】

Unknown