Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF

FEBS Letters

Brandenburger, Yves²  Autelitano, Dominic J¹  Woodcock, Elizabeth A²  Du, Xiao-Jun²  Gao, Xiao-ming²  Arthur, Jane F²  Hannan, Ross D²  Rothblum, Lawrence I³ 

[1] Cryptome Research Pty. Ltd., Baker Heart Research Institute, P.O. Box 6492, St Kilda Road Central, Melbourne, Vic. 8008, Australia;Molecular Cardiology, Baker Heart Research Institute, P.O. Box 6492, St Kilda Road Central, Melbourne, Vic. 8008, Australia;Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA

关键词: rDNA transcription;    Upstream binding factor;    Ribosome;    Left ventricular hypertrophy;    Cardiac hypertrophy;    Pressure overload;    ANP;    atrial natriuretic peptide;    ERK1/2;    extracellular signal-regulated kinases 1 and 2;    ETS;    external transcribed spacer;    GAPDH;    glyceraldehyde-3-phosphate dehydrogenase;    LV;    left ventricle;    LVH;    left ventricular hypertrophy;    RV;    right ventricle;    SH;    sham;    TAC;    transverse aortic constriction;    UBF;    upstream binding factor;   

DOI  :  10.1016/S0014-5793(03)00744-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1–6 weeks following transverse aortic constriction were significantly increased (2.5–3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.

【 授权许可】

Unknown