Regulation of ribosome biogenesis within the nucleolus

FEBS Letters

Huang, Sui¹  Leary, Daniel J¹ 

[1] Department of Cell and Molecular Biology, Northwestern University Medical School, 300 E. Chicago Ave, Chicago, IL 60611, USA

关键词: Regulation of ribosome biogenesis;    rDNA transcription;    Pre-rRNA processing and preribosomal particle assembly;    Intranuclear trafficking and dynamics;    rRNA;    ribosomal RNA;    Pol I;    RNA polymerase I;    rDNA;    ribosomal DNA;    SL-1;    selectivity factor 1;    UBF;    upstream binding factor;    CKII;    casein kinase II;    TTF-1;    transcription terminator factor 1;    pRb;    retinoblastoma protein;    HAT;    histone acetyltransferase;    CBP;    CREB-binding protein;    CPBF;    core promoter-binding factor;    RENT;    regulator of nucleolar silencing and telophase exit;    PKC;    protein kinase C;    FRAP;    fluorescence recovery after photobleaching;   

DOI  :  10.1016/S0014-5793(01)03143-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ribosome biogenesis is both necessary for cellular adaptation, growth, and proliferation as well as a major energetic and biosynthetic demand upon cells. For these reasons, ribosome biogenesis requires precise regulation to balance supply and demand. The complexity of ribosome biogenesis gives rise to many steps and opportunities where regulation could take place. For trans-acting factors involved in ribosome biogenesis in the nucleolus, there may be a dynamic coordination, both spatially and temporally, that regulates their functions from the transcription of rDNA to the assembly and export of preribosomal particles. Here we summarize most of the described regulations on ribosome biogenesis in the nucleolus. However, these may represent only a small fraction of a larger picture. Further studies are required to determine the initial signals, signal transduction pathways utilized, and the specific targets of these regulatory modifications and how these are used to control ribosome biogenesis as a whole.

【 授权许可】

Unknown