Resistin is expressed in different rat tissues and is regulated in a tissue‐ and gender‐specific manner

FEBS Letters

Nogueiras, Rubén³  Gallego, Rosalía⁴  Caminos, J.Eduardo³  García-Caballero, Tomás⁴  Gualillo, Oreste²  Casanueva, Felipe F.¹  Diéguez, Carlos³ 

[1] Department of Medicine-Molecular Endocrinology Section, University of Santiago de Compostela, School of Medicine, 15705 Santiago de Compostela, Spain;Hospital Clı́nico Universitario de Santiago, University of Santiago de Compostela, School of Medicine, 15705 Santiago de Compostela, Spain;Department of Physiology, University of Santiago de Compostela, School of Medicine, 15705 Santiago de Compostela, Spain;Department of Morphological Sciences, University of Santiago de Compostela, School of Medicine, 15705 Santiago de Compostela, Spain

关键词: Resistin;    Gender;    Fasting;    Obesity;   

DOI  :  10.1016/S0014-5793(03)00708-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Resistin is a polypeptide hormone first reported from human and rodent adipocytes. In order to better define the potential biological role of resistin we undertook a detailed analysis of its expression in different rat tissues. We demonstrate by real-time reverse transcription polymerase chain reaction, Southern blotting and immunohistochemistry that resistin is expressed not only in brown and white adipose tissue, but also in the stomach, small and large intestines, adrenal gland, and skeletal muscle. Food deprivation led to a decrease in resistin mRNA expression only in adipose tissue, not in any of the other tissues studied. Furthermore, resistin mRNA expression is higher in males than in females in adipose tissue, not in any of the other tissues. Thus, our data suggest that resistin is not exclusively localized in adipocytes, and indicate that its expression is regulated in a tissue- and sex-specific manner.

【 授权许可】

Unknown