Identification of RIP140 as a nuclear receptor cofactor with a role in female reproduction

FEBS Letters

Steel, Jennifer²  Leonardsson, Göran²  Milligan, Stuart¹  Parker, Malcolm²  White, Roger² 

[1] School of Biomedical Sciences, Kings College London, Guy's Campus, London Bridge, London SE1 1UL, UK;Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Rd, London W12 ONN, UK

关键词: Steroid hormones;    Corepressor;    RIP140;    Ovary;    RIP140;    receptor interacting protein with a molecular weight of 140 kDa;    HDACs;    histone deacetylases;    LXXLL;    peptide sequence where L is leucine and X is any amino acid;    CtBP;    carboxy-terminal binding protein;    LH;    luteinising hormone;    p.c.;    post-coitum;    COX-2;    cyclooxygenase 2;   

DOI  :  10.1016/S0014-5793(03)00564-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Nuclear receptors function as ligand-dependent transcription factors by recruiting cofactors that remodel chromatin and recruit the transcription machinery. RIP140 (receptor interacting protein with a molecular weight of 140 kDa) is a widely expressed corepressor that has the potential to inhibit the transcriptional activity of most, if not all nuclear receptors. Mice devoid of RIP140 indicate that it plays a crucial role in female fertility and in adipose biology. It is essential in the ovary for ovulation, specifically oocyte release but not luteinisation of mature follicles. Our goal is to identify the key nuclear receptor(s) and their target genes responsible for ovulation.

【 授权许可】

Unknown