New intracellular components of bone morphogenetic protein/Smad signaling cascades

FEBS Letters

Verschueren, Kristin¹  Huylebroeck, Danny¹  Zwijsen, An¹ 

[1] Department of Developmental Biology (VIB7), Flanders Interuniversity Institute for Biotechnology, and Laboratory of Molecular Biology (CELGEN), University of Leuven, Herestraat 49, 3000 Leuven, Belgium

关键词: Bone morphogenetic protein;    Signal transduction;    Smad;    Transforming growth factor-β;    ALK;    activin receptor-like kinase;    BMP;    bone morphogenetic protein;    BRE;    BMP response element;    CIZ;    Cas-interacting zinc finger protein;    co-Smad;    common mediator Smad;    GDF;    growth/differentiation factor;    Id;    inhibitor of differentiation;    I-Smad;    inhibitory Smad;    R-Smad;    receptor-activated Smad;    SARA;    Smad anchor for receptor activation;    SANE;    Smad1 antagonistic effector;    SBE;    Smad binding element;    SNIP;    Smad nuclear interacting protein;    TGF-β;    transforming growth factor-β;    OAZ;    Olf-1/EBF-associated zinc finger;   

DOI  :  10.1016/S0014-5793(03)00566-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bone morphogenetic proteins (BMPs) regulate many processes in the embryo, including cell type specification, patterning, apoptosis, and epithelial–mesenchymal interaction. They also act in soft and hard tissues in adult life. Their signals are transduced from the plasma membrane to the nucleus through a limited number of Smad proteins. The list of Smad-interacting proteins is however growing and it is clear that these partners determine the outcome of the signal. We summarize the present status in BMP/Smad signaling, with emphasis on recently identified Smad partners and how these proteins may cooperate in the regulation of the expression of BMP target genes.

【 授权许可】

Unknown