Search for new cyclic AMP‐binding proteins

FEBS Letters

Kopperud, R.¹  Maenhaut, C.²  Doskeland, S.O.¹  Dremier, S.²  Dumont, J.E.² 

[1] Department of Anatomy and Cell Biology, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway;IRIBHM, Faculty of Medicine, Free University of Brussels, 808 Route de Lennik, 1070 Brussels, Belgium

关键词: Cyclic AMP;    Cyclic nucleotide monophosphate-binding domain;    cAMP-binding protein;    cNMP;    cyclic nucleotide monophosphate;    PKA;    cAMP-dependent protein kinase;    CAP;    catabolite gene activator protein;    Epac;    exchange protein directly activated by cAMP;    CNG;    cyclic nucleotide-gated;    NTE;    neuropathy target esterase;    cAR;    cAMP receptor of Dictyoestelium;   

DOI  :  10.1016/S0014-5793(03)00561-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Today, there is evidence that the cAMP-dependent kinases (PKA) are not the only intracellular receptors involved in intracellular cAMP signalling in eukaryotes. Other cAMP-binding proteins have been recently identified, including some cyclic nucleotide-gated channels and Epac (exchange protein directly activated by cAMP) proteins. All these proteins bind cAMP through conserved cyclic nucleotide monophosphate-binding domains. However, all putative cAMP-binding proteins having such domains, as revealed by computer analysis, do not necessarily bind cAMP, indicating that their presence is not a sufficient criteria to predict cAMP-binding property for a protein.

【 授权许可】

Unknown