Phosphoinositide 3‐kinase‐dependent activation of Rac

FEBS Letters

Stephens, Len R.²  Welch, Heidi C.E.²  Coadwell, W.John¹  Hawkins, Phillip T.² 

[1] Bioinformatics Group, The Babraham Institute, Cambridge CB2 4AT, UK;Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge CB2 4AT, UK

关键词: Rac;    GTPase;    Phosphoinositide 3-kinase;    Guanine-nucleotide exchange factor;    Signalling;    PI3K;    phosphoinositide 3-kinase;    PtdIns(3;    4;    5)P3;    phosphatidylinositol (3;    4;    5)-triphosphate;    GEF;    guanine-nucleotide exchange factor;    GDI;    guanosine diphosphate dissociation inhibitor;    DH;    Dbl homology;    PH;    plextrin homology;   

DOI  :  10.1016/S0014-5793(03)00454-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The monomeric GTPase Rac and the lipid kinase phosphoinositide 3-kinase (PI3K) are intracellular signalling enzymes that each regulate a huge range of cellular functions. Their signalling pathways overlap. Several pathways lead from PI3K activation via the production of the lipid second messenger phosphatidylinositol (3,4,5)-triphosphate (PtdIns(3,4,5)P₃) to the activation of guanine-nucleotide exchange factors (GEFs) that activate Rac. Vice versa, Rac can also stimulate the activation of PI3K, although the mechanism for this is unclear. We review here the evidence that links PI3K and Rac signalling pathways.

【 授权许可】

Unknown