Regulation of Tiam1–Rac signalling

FEBS Letters

Mertens, Alexander E.¹  Collard, John G.¹  Roovers, Rob C.¹ 

[1] The Netherlands Cancer Institute, Department of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

关键词: Tiam1;    Rac;    GTPase;    Signalling;    Guanine nucleotide exchange factor;    Tumourigenesis;    CaMK-II;    Ca2+/calmodulin kinase II;    DH;    Dbl homology;    EDG2;    endothelial cell differentiation gene 2;    GAP;    GTPase-activating protein;    GDI;    guanine nucleotide dissociation inhibitor;    GEF;    guanine nucleotide exchange factor;    HA;    hyaluronic acid;    HER;    heregulin;    JIP/IB2;    JIP/islet-brain;    LPA;    lysophosphatidic acid;    PH;    pleckstrin homology;    PI3-kinase;    phosphatidyl inositol 3-kinase;    PKB;    protein kinase B;    PKC;    protein kinase C;    RBD;    Ras-binding domain;    Tiam1;    T-lymphoma invasion and metastasis;   

DOI  :  10.1016/S0014-5793(03)00435-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The GTPases of the Rho family are molecular switches that play an important role in a wide range of cellular processes and are increasingly implicated in tumourigenesis. Unlike what was found for the Ras oncogenes in tumours, hardly any activating mutations have been found in the genes encoding Rho proteins. In the past, we have identified Tiam1 (T-lymphoma invasion and metastasis) as a specific activator for the Rho-like GTPase Rac. In vivo, Tiam1 deficiency protects against Ras-induced skin carcinogenesis, underscoring the consequences of deregulated signalling for the onset and progression of tumours. Thus, an important level of regulation of signalling via the Rho-like GTPases comes from the specific control of their activators. In this paper, we review what is known on the specific regulation of Tiam1 signalling towards Rac.

【 授权许可】

Unknown