Protein kinase D: a family affair

FEBS Letters

Mikhalap, Svetlana¹  Seufferlein, Thomas²  Vandenheede, Jackie R.¹  De Kimpe, Line¹  Van Lint, Johan¹  Vantus, Tibor¹  Rykx, An¹ 

[1] Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium;Division of Internal Medicine, Faculty of Medicine, University of Ulm, Robert Kochstrasse 8, 09081 Ulm, Germany

关键词: Protein kinase D;    Protein kinase Cμ;    Cell proliferation;    Apoptosis;    Signal transduction;    Golgi apparatus;    Stress signaling;    Tumor cell invasion;    PKD;    protein kinase D;    PKC;    protein kinase C;    TGN;    trans-Golgi network;    PH;    pleckstrin homology;    DAG;    diacylglycerol;    PDBu;    phorbol dibutyrate;    PLC;    phospholipase C;    PMA;    phorbol-12;    13-myristate acetate;    ERK;    extracellular signal regulated kinase;    BCR;    B-cell receptor;    GPCR;    G-protein coupled receptor;    JNK;    Jun N-terminal kinase;    PA;    phosphatidic acid;   

DOI  :  10.1016/S0014-5793(03)00487-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCμ, PKD2 and PKD3/PKCν. They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation.

【 授权许可】

Unknown