MAP kinase‐mediated phosphoacetylation of histone H3 and inducible gene regulation

FEBS Letters

Mahadevan, Louis C.¹  Clayton, Alison L.¹ 

[1] Nuclear Signalling Laboratory, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK

关键词: Acetylation;    Immediate-early gene induction;    Mitogen-activated protein kinases;    Mitogen- and stress-activated protein kinase;    Phosphorylation;    Ribosomal S6 kinase;    BMK;    big mitogen-activated protein kinase;    CBP;    CREB binding protein;    CREB;    cAMP-responsive element binding protein;    EGF;    epidermal growth factor;    ERK/MAPK;    extracellular signal-regulated kinase/mitogen-activated protein kinase;    FSH;    follicle-stimulating hormone;    HAT;    histone acetyltransferases;    HDAC;    histone deacetylase;    HMG;    high mobility group;    IE gene;    immediate-early gene;    JNK/SAPK;    c-Jun amino-terminal kinase/stress-activated protein kinase;    MAP kinase;    mitogen--activated protein kinase;    MAPKAP-K1/RSK;    MAP kinase-activated protein kinase-1/ribosomal S6 kinase;    MSK;    mitogen- and stress-activated protein kinase;    PKA;    protein kinase A;   

DOI  :  10.1016/S0014-5793(03)00451-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

That signalling pathways, particularly the mitogen-activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re-evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation.

【 授权许可】

Unknown