Molecular mechanisms of insulin receptor substrate protein‐mediated modulation of insulin signalling

FEBS Letters

Pirola, Luciano¹  Johnston, Anne M.¹  Van Obberghen, Emmanuel¹ 

[1] INSERM Unit 145, IFR 50, Faculty of Medicine, Nice, France

关键词: Insulin;    Signalling;    IRS;    SOCS;    Phosphorylation;    RTK;    receptor tyrosine kinase;    SH2;    Src homology 2;    IRS;    insulin receptor substrate;    IR;    insulin receptor;    IGF-1R;    insulin-like growth factor-1 receptor;    PI3K;    phosphatidylinositol-3 kinase;    AMPK;    AMP-activated protein kinase;    PKB;    protein kinase B;    SOCS;    suppressor of cytokine signalling;    TNF;    tumour necrosis factor;   

DOI  :  10.1016/S0014-5793(03)00438-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The insulin receptor substrate (IRS) proteins act as important mediators of insulin action. Their regulation serves to augment the specificity of the insulin signalling cascade. They can be regulated – both positively and negatively – at the level of phosphorylation, and signalling through these proteins can be further modulated through the actions of SOCS (suppressor of cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide further insight into the pathophysiology of insulin resistance and type 2 diabetes.

【 授权许可】

Unknown