ATP synthesis driven by proton transport in F1F0‐ATP synthase

FEBS Letters

Senior, Alan E¹  Weber, Joachim¹ 

[1] Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA

关键词: ATP synthase;    Subunit rotation;    ATP synthesis;    ATP hydrolysis;    Molecular motor;    Proton transport;    NBD-Cl;    7-chloro-4-nitrobenzo-2-oxa-1;    3-diazole;    DCCD;    dicyclohexylcarbodiimide;    AMPPNP;    5′-adenylyl-β;    γ-imidodiphosphate;   

DOI  :  10.1016/S0014-5793(03)00394-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms.

【 授权许可】

Unknown