期刊论文详细信息
FEBS Letters | |
ATP synthesis driven by proton transport in F1F0‐ATP synthase | |
Senior, Alan E1  Weber, Joachim1  | |
[1] Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA | |
关键词: ATP synthase; Subunit rotation; ATP synthesis; ATP hydrolysis; Molecular motor; Proton transport; NBD-Cl; 7-chloro-4-nitrobenzo-2-oxa-1; 3-diazole; DCCD; dicyclohexylcarbodiimide; AMPPNP; 5′-adenylyl-β; γ-imidodiphosphate; | |
DOI : 10.1016/S0014-5793(03)00394-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020313045ZK.pdf | 641KB | download |