期刊论文详细信息
FEBS Letters
Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co‐inducibility during iron overload 1
Leroyer, Patricia1  Troadec, Marie-Bérengère1  Pigeon, Christelle1  Alizadeh, Mehdi2  Brissot, Pierre1  Courselaud, Brice1  Loréal, Olivier1  Ilyin, Gennady1 
[1]INSERM U522, Hôpital Pontchaillou, 35033 Rennes, France
[2]EFS Bretagne, 35033 Rennes, France
关键词: Hepcidin;    Genomic structure;    Expression;    Iron overload;    EST;    expressed sequence tags;    IAP;    intracisternal A-particle;    USF2;    upstream stimulatory factor 2;   
DOI  :  10.1016/S0014-5793(03)00329-6
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

In contrast to the human genome, the mouse genome contains two HEPC genes encoding hepcidin, a key regulator of iron homeostasis. Here we report a comparative analysis of sequence, genomic structure, expression and iron regulation of mouse HEPC genes. The predicted processed 25 amino acid hepcidin 2 peptide share 68% identity with hepcidin 1 with perfect conservation of eight cysteine residues. Both HEPC1 and HEPC2 genes have similar genomic organization and have probably arisen from a recent duplication of chromosome 7 region, including the HEPC ancestral gene and a part of the adjacent USF2 gene. Insertion of a retroviral intracisternal A-particle element was found upstream of the HEPC1 gene. Both genes are highly expressed in the liver and to a much lesser extent in the heart. In contrast to HEPC1, a high amount of HEPC2 transcripts was detected in the pancreas. Expression of both genes was increased in the liver during carbonyl–iron and iron–dextran overload. Overall our data suggest that both HEPC1 and HEPC2 genes are involved in iron metabolism regulation but could exhibit different activities and/or play distinct roles.

【 授权许可】

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