Physiologic cyclic stretch inhibits apoptosis in vascular endothelium

FEBS Letters

Wang, Hong¹  Durante, William¹  Ensenat, Diana¹  Schafer, Andrew I¹  Liu, Xiao-ming¹ 

[1] VA Medical Center and the Department of Medicine, Baylor College of Medicine, Building 109, Room 130, 2002 Holcombe Boulevard, Houston, TX 77030, USA

关键词: Cyclic stretch;    Endothelial cell;    Apoptosis;    ECs;    endothelial cells;    SDS–PAGE;    sodium dodecyl sulfate–polyacrylamide gel electrophoresis;    TNFα;    tumor necrosis factor-α;    PI3K;    phosphatidylinositol 3-kinase;   

DOI  :  10.1016/S0014-5793(03)00285-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Since apoptosis of endothelial cells (ECs) plays an important role in the pathogenesis of atherosclerosis, we investigated the effect of cyclic stretch on EC apoptosis. Application of moderate, physiologic levels of cyclic stretch (6–10% at 1 Hz) inhibited EC apoptosis. This anti-apoptotic effect was dependent on the activation of phosphatidylinositol 3-kinase and associated with the activation of Akt and the phosphorylation of Bad. Interestingly, a higher potentially pathologic level of cyclic stretch (20% at 1 Hz) stimulated EC apoptosis. The ability of physiologic cyclic stretch to inhibit EC apoptosis may provide a previously unrecognized mechanism by which hemodynamic forces exert an anti-atherogenic effect.

【 授权许可】

Unknown