Aquaporin‐9 is expressed in a mucus‐secreting goblet cell subset in the small intestine

FEBS Letters

Okada, Shinji¹  Misaka, Takumi¹  Matsumoto, Ichiro¹  Abe, Keiko¹  Watanabe, Hirohito² 

[1] Laboratory of Biological Function, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashi-mita, Tama-ku, Kawasaki 214-8571, Japan

关键词: Aquaporin;    Water channel;    Goblet cell;    Small intestine;    Large intestine;    AQP;    aquaporin;    DIG;    digoxigenin;    hAQP;    human aquaporin;    mAQP;    mouse aquaporin;    PAS;    periodic acid Schiff's stain;    PBS;    phosphate-buffered saline;   

DOI  :  10.1016/S0014-5793(03)00256-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We analyzed the expression of aquaporins (AQPs) in the small intestine to elucidate their functions, and found that AQP9, which had not previously been detected there, is present in duodenum, jejunum, and ileum. AQP9 is expressed in colon as well, but not in stomach. Also, its expression in these intestinal sections is limited to the basolateral membranes of a goblet cell subset. Our finding that AQP9 is present specifically in goblet cells as mucus-secreting cells suggests its involvement in the synthesis and/or secretion of a certain kind of mucus which may protect the intestinal surface and smooth the flow of intestinal contents.

【 授权许可】

Unknown