DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration?

FEBS Letters

Kang, Weiqun¹  Reid, Kenneth B.M¹ 

[1] MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK

关键词: Deleted in malignant brain tumor 1;    Mucosal defense;    Epithelial differentiation;    Tumorigenesis;    Salivary agglutinin;    SRCR;    scavenger receptor cysteine rich;    DMBT1;    deleted in malignant brain tumor 1;    LOHs;    losses of heterozygosity;    SID;    SRCR-interspersed domain;    CUB;    C1r/C1s Uegf Bmp1;    ZP;    zona pellucida;    RT-PCR;    reverse transcriptase-polymerase chain reaction;    sIgA;    soluble immunoglobulin A;    SP-D;    surfactant protein D;    SP-A;    surfactant protein A;   

DOI  :  10.1016/S0014-5793(03)00217-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

DMBT1 (deleted in malignant brain tumor 1), which encodes a large scavenger receptor cysteine rich (SRCR) B protein, has been proposed to be a tumor suppressor gene, due to the high frequency of its homozygous deletion and the lack of expression in a variety of cancers. However, studies on its physiological functions and its relationship with tumorigenesis are still at an initial stage. Two mucosal defense-related molecules, gp-340 and salivary agglutinin, have been identified to be alternatively spliced products of DMBT1, which suggests that DMBT1 is a pattern recognition receptor in innate immunity. Meanwhile, results from immunohistochemical staining and studies at the cellular level, began to associate DMBT1 with a proliferation to differentiation switching process in gastrointestinal epithelial cells. Together with its up-regulation in inflammation, these findings suggest that DMBT1 might be a local regulator of homeostasis, possibly through linking mucosal inflammation to the modulation of epithelial regeneration, and whose abnormality is a frequent cause of malignancy.

【 授权许可】

Unknown