FEBS Letters | |
DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration? | |
Kang, Weiqun1  Reid, Kenneth B.M1  | |
[1] MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK | |
关键词: Deleted in malignant brain tumor 1; Mucosal defense; Epithelial differentiation; Tumorigenesis; Salivary agglutinin; SRCR; scavenger receptor cysteine rich; DMBT1; deleted in malignant brain tumor 1; LOHs; losses of heterozygosity; SID; SRCR-interspersed domain; CUB; C1r/C1s Uegf Bmp1; ZP; zona pellucida; RT-PCR; reverse transcriptase-polymerase chain reaction; sIgA; soluble immunoglobulin A; SP-D; surfactant protein D; SP-A; surfactant protein A; | |
DOI : 10.1016/S0014-5793(03)00217-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
DMBT1 (deleted in malignant brain tumor 1), which encodes a large scavenger receptor cysteine rich (SRCR) B protein, has been proposed to be a tumor suppressor gene, due to the high frequency of its homozygous deletion and the lack of expression in a variety of cancers. However, studies on its physiological functions and its relationship with tumorigenesis are still at an initial stage. Two mucosal defense-related molecules, gp-340 and salivary agglutinin, have been identified to be alternatively spliced products of DMBT1, which suggests that DMBT1 is a pattern recognition receptor in innate immunity. Meanwhile, results from immunohistochemical staining and studies at the cellular level, began to associate DMBT1 with a proliferation to differentiation switching process in gastrointestinal epithelial cells. Together with its up-regulation in inflammation, these findings suggest that DMBT1 might be a local regulator of homeostasis, possibly through linking mucosal inflammation to the modulation of epithelial regeneration, and whose abnormality is a frequent cause of malignancy.
【 授权许可】
Unknown
【 预 览 】
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