FEBS Letters | |
Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch | |
Kranenburg, O.1  van der Eb, A.J.1  Zantema, A.1  | |
[1] Department of Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands | |
关键词: Retinoblastoma gene product; Differentiation; Tumorigenesis; Cyclin-dependent kinase; | |
DOI : 10.1016/0014-5793(95)00587-Y | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The retinoblastoma susceptibility gene (RB1) is essential for normal embryonic development. Loss of RB1 leads to uncontrolled proliferation of a number of cell types but may also prevent proper terminal differentiation. The growth-suppressive and differentiation-inducing properties of pRb are impaired by cyclin-dependent kinase (cdk)-mediated phosphorylation. Hence, inhibition of cdk activity is probably a prerequisite for terminal differentiation. Indeed, forced cyclin or cdk expression can prevent terminal differentiation in various cell types, probably through inhibition of pRb and, possibly, differentiation-specific transcription factors.
【 授权许可】
Unknown
【 预 览 】
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