Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch

FEBS Letters

Kranenburg, O.¹  van der Eb, A.J.¹  Zantema, A.¹ 

[1] Department of Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, P.O. Box 9503, 2300 RA Leiden, The Netherlands

关键词: Retinoblastoma gene product;    Differentiation;    Tumorigenesis;    Cyclin-dependent kinase;   

DOI  :  10.1016/0014-5793(95)00587-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The retinoblastoma susceptibility gene (RB1) is essential for normal embryonic development. Loss of RB1 leads to uncontrolled proliferation of a number of cell types but may also prevent proper terminal differentiation. The growth-suppressive and differentiation-inducing properties of pRb are impaired by cyclin-dependent kinase (cdk)-mediated phosphorylation. Hence, inhibition of cdk activity is probably a prerequisite for terminal differentiation. Indeed, forced cyclin or cdk expression can prevent terminal differentiation in various cell types, probably through inhibition of pRb and, possibly, differentiation-specific transcription factors.

【 授权许可】

Unknown