A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

FEBS Letters

Ivanov, D.V.¹  Lemonnier, L.²  Kononenko, N.²  Prevarskaya, N.²  Pestova, A.A.¹  Yankovsky, N.K.¹  Nikitin, E.A.³  Baranova, A.V.¹  Panchin, Y.V.²  Skryma, R.²  Tyazhelova, T.V.¹ 

[1] Vavilov Institute of General Genetics, 3 Gubkina Str., 119991 Moscow, Russia;Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, Bâtiment SN3, USTL, 59655 Villeneuve d’Ascq, France;Hematology Research Center of Russia, Novozykovski pr.4a, 125167 Moscow, Russia

关键词: Tumor suppressor gene;    B-cell chronic lymphocytic leukemia;    Prostate cancer;    13q14.3;    K+ channel regulating protein;   

DOI  :  10.1016/S0014-5793(03)00211-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K⁺ channels. Using the patch-clamp technique we determined that KCNRG suppresses K⁺ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K⁺ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.

【 授权许可】

Unknown