FEBS Letters | |
Meltrin β mini, a new ADAM19 isoform lacking metalloprotease and disintegrin domains, induces morphological changes in neuronal cells1 | |
Kurisaki, Tomohiro1  Sehara-Fujisawa, Atsuko1  Wakatsuki, Shuji1  | |
[1] Department of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan | |
关键词: Dorsal root ganglion; N1E-115; Neurite outgrowth; Neurogenesis; DRG; dorsal root ganglion; | |
DOI : 10.1016/S0014-5793(02)03732-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Meltrin β (ADAM19) is a metalloprotease-disintegrin expressed in the peripheral nervous system and other organs during embryogenesis. We report here an alternatively spliced isoform, meltrin β mini, that lacks the prodomain, metalloprotease and disintegrin domains. A comparison of the cDNA and genomic sequences suggested the existence of a new exon. This isoform was detected in murine dorsal root ganglion and neuronal cell lines by RT-PCR. Overexpression of meltrin β mini but not meltrin β induced neurite outgrowth in neuronal cells. These studies suggest that the novel meltrin β isoform has a distinct function related to neurogenesis.
【 授权许可】
Unknown
【 预 览 】
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RO201912020312542ZK.pdf | 140KB | download |