Meltrin β mini, a new ADAM19 isoform lacking metalloprotease and disintegrin domains, induces morphological changes in neuronal cells1

FEBS Letters

Kurisaki, Tomohiro¹  Sehara-Fujisawa, Atsuko¹  Wakatsuki, Shuji¹ 

[1] Department of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan

关键词: Dorsal root ganglion;    N1E-115;    Neurite outgrowth;    Neurogenesis;    DRG;    dorsal root ganglion;   

DOI  :  10.1016/S0014-5793(02)03732-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Meltrin β (ADAM19) is a metalloprotease-disintegrin expressed in the peripheral nervous system and other organs during embryogenesis. We report here an alternatively spliced isoform, meltrin β mini, that lacks the prodomain, metalloprotease and disintegrin domains. A comparison of the cDNA and genomic sequences suggested the existence of a new exon. This isoform was detected in murine dorsal root ganglion and neuronal cell lines by RT-PCR. Overexpression of meltrin β mini but not meltrin β induced neurite outgrowth in neuronal cells. These studies suggest that the novel meltrin β isoform has a distinct function related to neurogenesis.

【 授权许可】

Unknown