Identification of 30 protein species involved in replicative senescence and stress‐induced premature senescence

FEBS Letters

Wenders, Frédéric¹  Raes, Martine¹  Dierick, Jean-François¹  Roepstorff, Peter²  Dieu, Marc¹  Kalume, Dário E²  Salmon, Michel¹  Toussaint, Olivier¹ 

[1] Unit of Research on Cellular Biology (URBC), Department of Biology, University of Namur (FUNDP), Rue de Bruxelles 61, B-5000 Namur, Belgium;Protein Research Group, University of Southern Denmark/Odense University, Campusvej 55, DK-5230 Odense M, Denmark

关键词: Stress;    Replicative senescence;    Proteomics;    Mass spectrometry;    Molecular scars;    In vitro toxicology;   

DOI  :  10.1016/S0014-5793(02)03604-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Exposure of human proliferative cells to subcytotoxic stress triggers stress-induced premature senescence (SIPS) which is characterized by many biomarkers of replicative senescence. Proteomic comparison of replicative senescence and stress-induced premature senescence indicates that, at the level of protein expression, stress-induced premature senescence and replicative senescence are different phenotypes sharing however similarities. In this study, we identified 30 proteins showing changes of expression level specific or common to replicative senescence and/or stress-induced premature senescence. These changes affect different cell functions, including energy metabolism, defense systems, maintenance of the redox potential, cell morphology and transduction pathways.

【 授权许可】

Unknown