Expression and regulation of peroxiredoxin 5 in human osteoarthritis

FEBS Letters

Wei, Aiqun¹  Murrell, George A.C¹  Knoops, Bernard²  Yuan, Jun¹  Trickett, Annette³  Wang, Min-Xia¹ 

[1] Orthopaedic Research Institute, St George Hospital, University of New South Wales, Sydney, NSW 2217, Australia;Laboratory of Cell Biology, ISV, Université Catholique de Louvain, Place Croix du Sud, 5, 1348 Louvain-la-Neuve, Belgium;Clinical Hematology, St George Hospital, University of New South Wales, Sydney, NSW 2217, Australia

关键词: Osteoarthritis;    Peroxiredoxin 5;    Oxidative stress;    Reactive oxygen species;    Articular cartilage;    Antioxidant;    OA;    osteoarthritis;    PRDX5;    peroxiredoxin 5;    ROS;    reactive oxygen species;   

DOI  :  10.1016/S0014-5793(02)03511-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Reactive oxygen species (ROS) are implicated in the pathogenesis of osteoarthritis (OA). However, little is known about the antioxidant defence system in articular cartilage. We investigated the expression and regulation of peroxiredoxin 5 (PRDX5), a newly discovered thioredoxin peroxidase, in human normal and osteoarthritic cartilage. Our results show that human cartilage constitutively expresses PRDX5. Moreover, the expression is up-regulated in OA. Inflammatory cytokines tumour necrosis factor α and interleukin 1 β contribute to this up-regulation by increasing intracellular ROS production. The present study suggests that PRDX5 may play a protective role against oxidative stress in human cartilage.

【 授权许可】

Unknown