Glycosphingolipid‐dependent cross‐talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy

FEBS Letters

Hakomori, Senitiroh¹  Handa, Kazuko¹ 

[1] Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122-4327, USA

关键词: Glycosylation-dependent cell adhesion;    Tumor-associated ganglioside;    Interfacing;    Signal transduction;    Glycosynapse;    Microenvironment;    BM;    basement membrane;    EC;    endothelial cell;    EpC;    epithelial cell;    GEM;    glycolipid-enriched microdomain;    GSL;    glycosphingolipid;    PBMC;    peripheral blood mononuclear cells;    PL;    proteolipid (hydrophobic protein soluble in chloroform-methanol);    T1–T6;    stages of tumors as defined in the figure legend and the text;    TD;    signal transducer;   

DOI  :  10.1016/S0014-5793(02)03479-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Status of tumor progression (either remaining in situ, or becoming invasive/metastatic) may be defined largely by subtle interactions (‘cross-talk’) in a microenvironment formed by interfacing tumor cell and host cell membrane domains (termed ‘glycosynapses’) involved in glycosylation-dependent cell adhesion and signaling. Functional roles of tumor-associated gangliosides, organized in glycosynapses of three types of tumor cell lines, are discussed. Gangliosides function as adhesion receptors or as ‘sensors’ that can be stimulated by antibodies, with consequent activation of signal transducers leading to enhanced motility and invasiveness.

【 授权许可】

Unknown