Phospholipase A2 regulation of arachidonic acid mobilization

FEBS Letters

Balsinde, Jesús¹  Winstead, Michelle V²  Dennis, Edward A² 

[1] Institute of Molecular Biology and Genetics, Spanish Council for Scientific Research, University of Valladolid School of Medicine, 47005 Valladolid, Spain;Department of Chemistry and Biochemistry, School of Medicine and Revelle College, University of California at San Diego, La Jolla, CA 92093-0601, USA

关键词: Arachidonic acid;    Eicosanoid metabolism;    Phospholipase;    Inflammation;    AA;    arachidonic acid;    PLA2;    phospholipase A2;    cPLA2;    cytosolic Ca2+-dependent phospholipase A2;    iPLA2;    cytosolic Ca2+-independent phospholipase A2;    sPLA2;    secretory phospholipase A2;    PAF;    platelet-activating factor;    LPS;    bacterial lipopolysaccharide;   

DOI  :  10.1016/S0014-5793(02)03413-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Phospholipase A₂ (PLA₂) constitutes a growing superfamily of lipolytic enzymes, and to date, at least 19 distinct enzymes have been found in mammals. This class of enzymes has attracted considerable interest as a pharmacological target in view of its role in lipid signaling and its involvement in a variety of inflammatory conditions. PLA₂s hydrolyze the sn-2 ester bond of cellular phospholipids, producing a free fatty acid and a lysophospholipid, both of which are lipid signaling molecules. The free fatty acid produced is frequently arachidonic acid (AA, 5,8,11,14-eicosatetraenoic acid), the precursor of the eicosanoid family of potent inflammatory mediators that includes prostaglandins, thromboxanes, leukotrienes and lipoxins. Multiple PLA₂ enzymes are active within and surrounding the cell and these enzymes have distinct, but interconnected roles in AA release.

【 授权许可】

Unknown