Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes

FEBS Letters

de Kleijn, Dominique P.V¹  Lim, Sai-Kiang²  Velema, Evelyn¹  Smeets, Mirjam B¹  van Middelaar, Ben¹  Pasterkamp, Gerard¹ 

[1] Experimental Cardiology Laboratory, University Medical Center, Heidelberglaan 100 (room G02.523), 3584 CX Utrecht, The Netherlands;Genome Institute of Singapore, Singapore

关键词: Arterial remodeling;    Nitric oxide;    Haptoglobin;    Flow change;   

DOI  :  10.1016/S0014-5793(02)03343-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin-6 (IL-6). In the artery, shear stress and NO influence IL-6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL-6 levels. However, IL-6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression.

【 授权许可】

Unknown