Maternal carotid remodeling and increased carotid arterial stiffness in normal late-gestational pregnancy as assessed by radio-frequency ultrasound technique

BMC Pregnancy and Childbirth

Ning Zhou¹  Tie-Sheng Cao¹  Yun-You Duan¹  Dan Xue¹  Li-Jun Yuan¹ 

[1] Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China

关键词: Arterial remodeling;    Normal pregnancy;    Carotid artery;    Intima-media thickness;    Arterial stiffness;   

Others  :  1138018
DOI  :  10.1186/1471-2393-13-122

 received in 2013-02-17, accepted in 2013-05-21,  发布年份 2013

【 摘 要 】

Background

The adaption of elastic arteries to transient increase in hemodynamic load in normal pregnancy (NP) remains controversial. The purpose of this study was to investigate the NP carotid remodeling and regional arterial stiffness before and after parturition.

Methods

Fifty-one NP women and 30 age-matched non-pregnant women were included. All women underwent right common carotid artery (RCCA) measurements with MylabTwice ultrasound instrument (Esaote, Italy). Carotid intima-medial thickness (IMT), pulse wave velocity (PWV, m/s), distensibility coefficient (DC, 1/KPa), α, β, augmentation index (AIx, %) and carotid arterial pressure were obtained by the newly developed ultrasound vascular wall tracking methods: automatic QAS (Quality Arterial Stiffness) and QIMT (Quality Intima-Medial Thickness) Follow up study was performed.

Results

Compared to the non-pregnant controls, the arterial pressures were significantly increased and RCCA diameter was significantly enlarged in late gestational NP women. Twenty months after parturition, carotid diameter, DC, AIx, PWV and arterial wall tension were significantly decreased and had no significant difference with those in non-pregnant controls.

Conclusions

Carotid arterial remodeling and stiffening could be seen in the normal pregnant women, which seems to be a physiological adaption and could be recovered post partum. QIMT and QAS together could provide a comprehensive assessment of the maternal carotid arterial changes during pregnancy.

【 授权许可】

   
2013 Yuan et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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