E2F1 pathways to apoptosis

FEBS Letters

Ginsberg, Doron¹ 

[1] Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel

关键词: E2F;    Apoptosis;    p14ARF;    p53;    p73;    ApafI;   

DOI  :  10.1016/S0014-5793(02)03270-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation and their activity is often deregulated in human tumors. Recent studies demonstrate that E2F1 can induce both proliferation and apoptosis. E2F1-induced apoptosis occurs via multiple pathways, some of which induce stabilization and activation of the tumor suppressor p53. The pro-apoptotic activity of E2F1 suggests that its deregulation constitutes an oncogenic stress that may target pre-malignant cells to undergo apoptosis, thus preventing tumor development.

【 授权许可】

Unknown