Biochemistry of arsenic detoxification

FEBS Letters

Rosen, Barry P¹ 

[1] Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI 48201 USA

关键词: Arsenic;    Transport ATPase;    Resistance pump;    Arsenate reductase;   

DOI  :  10.1016/S0014-5793(02)03186-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

All living organisms have systems for arsenic detoxification. The common themes are (a) uptake of As(V) in the form of arsenate by phosphate transporters, (b) uptake of As(III) in the form of arsenite by aquaglyceroporins, (c) reduction of As(V) to As(III) by arsenate reductases, and (d) extrusion or sequestration of As(III). While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.

【 授权许可】

Unknown