Is Ca2+‐ATPase a water pump?

FEBS Letters

Dupont, Yves¹ 

[1] Laboratoire de Biophysique Moléculaire et Cellulaire, Equipe de Recherche CNRS No. 199, Département de Recherches Fondamentales, Centre d'Etudes Nucléaires de Grenoble, 38041 Grenoble, France

关键词: Transport ATPase;    Energy transduction;    Water;    Sarcoplasmic reticulum;    Calcium;    Phosphorylation;   

DOI  :  10.1016/0014-5793(83)80721-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mechanism of free energy coupling in active transport is discussed with special reference to the sarcoplasmic reticulum Ca²⁺-ATPase. In the current working schemes for cation transport ATPases, free energy transduction is nearly always based on enzyme conformational changes. The principal objective of the present article is to examine whether recent experimental results on Ca²⁺-ATPase may in fact be better explained by assuming the existence of a direct chemiosmotic process. In the scheme proposed, free energy transduction between ATP and calcium is based on a transfer of solvation water between the acylphosphate bond and the bound calcium ions.

【 授权许可】

Unknown