Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin

FEBS Letters

Sandvig, Kirsten¹  van Deurs, Bo² 

[1] Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway;Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

关键词: Ricin;    Cholera toxin;    Shiga toxin;    Endocytosis;    Golgi apparatus;    Clathrin;   

DOI  :  10.1016/S0014-5793(02)03182-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ricin, cholera, and Shiga toxin belong to a family of protein toxins that enter the cytosol to exert their action. Since all three toxins are routed from the cell surface through the Golgi apparatus and to the endoplasmic reticulum (ER) before translocation to the cytosol, the toxins are used to study different endocytic pathways as well as the retrograde transport to the Golgi and the ER. The toxins can also be used as vectors to carry other proteins into the cells. Studies with protein toxins reveal that there are more pathways along the plasma membrane to ER route than originally believed.

【 授权许可】

Unknown