Endocytosis and intracellular sorting of ricin and Shiga toxin

FEBS Letters

Sandvig, Kirsten¹  van Deurs, Bo² 

[1] Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway;Structural Cell Biology Unit, Department of Anatomy, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

关键词: Endocytosis;    Ricin;    Shiga toxin;    Golgi apparatus;    Endoplasmic reticulum;   

DOI  :  10.1016/0014-5793(94)00281-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ricin and Shiga toxin belong to a group of protein toxins with targets in the cytosol. These toxins consist of one moiety that binds the toxin molecule to cell surface receptors, and another enzymatically active moiety that enters the cytosol after endocytic uptake of the toxin. The toxins are of current interest in relation to disease and the construction of immunotoxins. Moreover, they have proven useful to investigate mechanisms of endocytosis and to follow intracellular pathways of transport. Some of the recent results obtained with ricin and Shiga toxin are discussed.

【 授权许可】

Unknown