Glycogen synthase: towards a minimum catalytic unit?

FEBS Letters

Cid, Emili¹  Ferrer, Juan C¹  Geremia, Roberto A²  Guinovart, Joan J¹ 

[1] Departament de Bioquı́mica i Biologia Molecular, Universitat de Barcelona, Martı́ i Franquès 1, E-08028 Barcelona, Spain;Plasticité et Expression des Génomes Microbiens, Université Joseph Fourier and Centre National de la Recherche Scientifique, FRE 2383, Bat. CERMO, BP 53X, 38041 Grenoble Cedex 9, France

关键词: Polysaccharide synthases;    Glycosyltransferases;    Glycogen;    Starch;    Evolution;    GS;    glycogen synthase;    G(S)S;    glycogen starch synthase;    HsMGS;    human muscle glycogen synthase;    Glc 6-P;    glucose 6-phosphate;    GlcNAc;    N-acetylglucosamine;   

DOI  :  10.1016/S0014-5793(02)03313-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Classically, α-1,4-glucan synthases have been divided into two families, animal/fungal glycogen synthases (GS) and bacterial/plant starch synthases (G(S)S), according to differences in sequence, sugar donor specificity and regulatory mechanisms. Detailed sequence analysis, predicted secondary structure comparison and threading analysis show that these two families are structurally related and that some domains of GSs were acquired to meet regulatory requirements. Archaeal G(S)S present structural and functional features that are conserved in one, the other or both families. Therefore, they are the link between GS and G(S)S and harbor the minimal sequence and structural features that constitute the minimum catalytic unit of the α-1,4-glucan synthase superfamily.

【 授权许可】

Unknown