Estrogens prevent calcium‐induced release of cytochrome c from heart mitochondria

FEBS Letters

Borutaite, Vilmante¹  Morkuniene, Ramune¹  Jekabsone, Aiste¹ 

[1] Institute for Biomedical Research, Kaunas University of Medicine, LT-3007 Kaunas, Lithuania

关键词: Heart;    Mitochondria;    Estrogen;    Cytochrome c;    Respiration;   

DOI  :  10.1016/S0014-5793(02)02820-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We investigated the effect of estrogens on heart mitochondrial functions and whether estrogens can prevent calcium-induced release of cytochrome c from mitochondria. 10 nM–10 μM 17β-estradiol or 4-hydroxytamoxifen did not affect mitochondrial respiration rate and membrane potential in state 3 and state 4. Higher concentrations of both agents decreased state 3 respiration rate and membrane potential. 100 nM 17β-estradiol and 4-hydroxytamoxifen blocked high calcium-induced cytochrome c release from mitochondria but not mitochondrial swelling. Thus, at physiological concentrations estrogens do not affect mitochondrial respiratory functions but protect heart mitochondria from high calcium-induced release of cytochrome c.

【 授权许可】

Unknown