Kinetic alterations of cytochrome‐c oxidase in cystic fibrosis

FEBS Letters

Lenaz, Giorgio²  Rugolo, Michela²  Battino, Maurizio²  Romeo, Giovanni¹ 

[1] Istituto G. Gaslini, Genova, Italy;Lab. di Biochimica, Istituto Botanico, Universita' di Bologna, Via Irnerio 42, 40126 Bologna, Italy

关键词: Cystic fibrosis;    Fibroblast;    Mitochondria;    Cytochrome-c oxidase;    Cytochrome c;   

DOI  :  10.1016/0014-5793(86)80470-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We compared the kinetics of cytochrome-c oxidase (cytochrome-c: oxygen oxidoreductase, EC 1.9.3.1) in fibroblasts derived from normal and cystic fibrosis individuals. The K _m of the enzyme for reduced cytochrome c was significantly increased in CF cells; the change, however, was observed only at temperatures above 25°C. The V _max values were comparable in both types of individuals.

【 授权许可】

Unknown