Short‐time non‐enzymatic nitric oxide synthesis from L‐arginine and hydrogen peroxide induced by shock waves treatment

FEBS Letters

Russo, S.¹  Suzuki, H.⁴  Marlinghaus, E.²  Amelio, E.⁵  Musci, G.³  Gotte, G.⁴ 

[1] Dipartimento di Ortopedia, Policlinico ‘Federico II’, Università di Napoli, Napoli, Italy;Biomedical Research Center, Storz Medical AG, Kreutzlingen, Switzerland;Department of Microbiological Genetic and Molecular Sciences, University of Messina, 98166 Messina, Italy;Dipartimento di Scienze Neurologiche e della Visione, Sezione di Chimica Biologica, Università di Verona, Verona, Italy;Unità Operativa di Chirurgia della Mano, Servizio di Terapia con Onde d'Urto, Policlinico ‘G.B. Rossi’, Azienda Ospedaliera di Verona, Verona, Italy

关键词: Shock waves;    Non-enzymatic nitric oxide;    SW;    shock wave;    NOS;    nitric oxide synthase;    MGD;    N-methyl-D-glucamine dithiocarbamate;    DAN;    2;    3-diaminonaphthalene;   

DOI  :  10.1016/S0014-5793(02)02807-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The evidence that nitric oxide (NO) production is possible by a non-enzymatic pathway has already been shown under restrictive experimental conditions. Here we show that NO can non-enzymatically be formed with short-time kinetics (min), by ‘bombing’ with shock waves a solution containing 1 mM hydrogen peroxide and 10 mM L-arginine. This procedure is widening its medical application with surprisingly positive effects in tissue regeneration and our finding could be one of the first steps for the understanding of the biochemical responsible for these therapeutical effects.

【 授权许可】

Unknown