Group B streptococcus (GBS) modifies macrophage phosphatidylserine metabolism during induction of apoptosis

FEBS Letters

Buratta, Sandra²  Marconi, Pierfrancesco¹  Mozzi, Rita²  Fetriconi, Ilaria¹  Fettucciari, Katia¹  Mambrini, Raffaela² 

[1] Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, 06122 Perugia, Italy;Department of Internal Medicine, Biochemistry Section, University of Perugia, 06122 Perugia, Italy

关键词: Phosphatidylserine;    Apoptosis;    Macrophage;    Group B streptococcus;    PtdSer;    phosphatidylserine;    PtdEtn;    phosphatidylethanolamine;    PtdCho;    phosphatidylcholine;    lysoPtdSer;    lysophosphatidylserine;    GBS;    group B streptococcus;    gGBS;    group B streptococcus grown in the presence of glucose;    SBEE;    serine base exchange enzyme;   

DOI  :  10.1016/S0014-5793(02)02769-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Group B streptococcus (GBS) induced macrophage apoptosis by which it could avoid host defence mechanisms. Macrophages, which constitutively express phosphatidylserine (PtdSer) on the outer leaflet of plasma membrane, increased PtdSer exposure during GBS-induced apoptosis. Induction of apoptosis decreased PtdSer radioactivity of macrophages incubated with [³H]serine. The effect appeared not due to increasing conversion of PtdSer to phosphatidylethanolamine or phosphatidylcholine nor to the release of radioactive membrane vesicles. The radioactivity in lysoPtdSer was also reduced. These results confirm that induction of apoptosis involves a modification of PtdSer metabolism and point out the typical features of the GBS-induced apoptosis with respect to other models of apoptosis.

【 授权许可】

Unknown