Novel cDNAs encoding salivary proteins from the malaria vector Anopheles gambiae

FEBS Letters

Santolamazza, Federica²  Veneri, Massimiliano²  Lombardo, Fabrizio²  Castrignanò, Tiziana¹  Lanfrancotti, Alessandra²  Arcà, Bruno²  Coluzzi, Mario² 

[1] CASPUR – Supercomputing Center for University and Research, c/o University ‘La Sapienza’, P.le Aldo Moro 5, 00185 Rome, Italy;Department of Public Health, Parasitology Unit, University ‘La Sapienza’, P.le Aldo Moro 5, P.O. Box 6 – Roma 62, 00185 Rome, Italy

关键词: Mosquito;    Salivary gland;    Saliva;    Hematophagy;   

DOI  :  10.1016/S0014-5793(02)02578-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several genes encoding salivary components of the mosquito Anopheles gambiae were identified using a selective trapping approach. Among these, five corresponded to genes expressed specifically in female glands and their role may possibly be linked to blood-feeding. Our collection included a fourth member of the D7 protein family and two polypeptides that showed weak similarity to anti-coagulants from distantly related species. Moreover, we identified two additional members of a novel group of proteins that we named glandins. The isolation of tissue-specific genes represents a first step toward a deeper molecular analysis of mosquito salivary secretions.

【 授权许可】

Unknown