Excess noise in modified conductance states following the interaction of ryanoids with cardiac ryanodine receptor channels

FEBS Letters

Williams, Alan J²  Tanna, Bhavna²  Sutko, John L⁴  Ruest, Luc¹  Welch, William³ 

[1] Department of Chemistry, University of Sherbrooke, Sherbrooke, QC, Canada JK1 2R1;Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK;Department of Biochemistry, University of Nevada School of Medicine, Reno, NV 89557, USA;Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA

关键词: Calcium-release channel;    Sarcoplasmic reticulum;    Ryanodine receptor;    Ryanodine;   

DOI  :  10.1016/S0014-5793(02)02462-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The interaction of ryanodine with the ryanodine receptor (RyR) produces profound changes in channel function. Open probability increases dramatically and conductance is reduced. In this report we describe differences in the properties of reduced conductance states produced by the interaction of ryanodine derivatives with RyR channels. Some reduced conductance states are considerably noisier than the normal open state of the RyR channel. Inspection and analysis of these events reveals that the excess noise arises from transitions between two conductance states. Following the interaction of certain ryanodine derivatives, RyR channels undergo transitions between two conformations with slightly different ion-handling properties.

【 授权许可】

Unknown