Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e)

FEBS Letters

Hershey, John W.B¹  Mayeur, Greg L¹ 

[1] Department of Biological Chemistry, School of Medicine, University of California, Davis, CA 95616, USA

关键词: Protein synthesis;    Translation initiation;    eIF3;    Int6;    Malignant transformation;    FCS;    fetal calf serum;    eIF;    eukaryotic initiation factor;    LOH;    loss of heterozygosity;   

DOI  :  10.1016/S0014-5793(02)02307-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several components of translation, e.g. eIF4E and PKR, are implicated in cancer. The e-subunit (p48) of mammalian initiation factor 3 is encoded by the Int6 gene, a common site for integration of the mouse mammary tumor virus genome, leading to the production of a truncated eukaryotic initiation factor-3e (eIF3e). Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation by four criteria: foci formation; anchorage independent growth; accelerated growth; and lack of contact inhibition. Stable expression of full-length eIF3e does not cause transformation. The truncated eIF3e also inhibits the onset of apoptosis caused by serum starvation.

【 授权许可】

Unknown