Elongation factor‐2 kinase and its newly discovered relatives

FEBS Letters

Ryazanov, Alexey G.¹ 

[1] Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway NJ 08854, USA

关键词: Elongation factor-2;    Protein kinase;    Protein phosphorylation;    α-Kinase;    Ion channel;    Channel-kinase;    TRP channels;   

DOI  :  10.1016/S0014-5793(02)02299-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Phosphorylation of elongation factor-2 (eEF-2) by the highly specific eEF-2 kinase results in eEF-2 inactivation and, therefore, may regulate the global rate of protein synthesis in animal cells. Cloning and sequencing of eEF-2 kinase led to the discovery of a new family of protein kinases, named α-kinases, whose catalytic domains display no sequence homology to conventional eukaryotic protein kinases. Several mammalian α-kinases have recently been cloned. Two of these α-kinases, named channel-kinases 1 and 2 (ChaK1 and ChaK2) represent a new type of signaling molecules that are protein kinases fused to ion channels.

【 授权许可】

Unknown