FEBS Letters | |
Elongation factor‐2 kinase and its newly discovered relatives | |
Ryazanov, Alexey G.1  | |
[1] Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway NJ 08854, USA | |
关键词: Elongation factor-2; Protein kinase; Protein phosphorylation; α-Kinase; Ion channel; Channel-kinase; TRP channels; | |
DOI : 10.1016/S0014-5793(02)02299-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Phosphorylation of elongation factor-2 (eEF-2) by the highly specific eEF-2 kinase results in eEF-2 inactivation and, therefore, may regulate the global rate of protein synthesis in animal cells. Cloning and sequencing of eEF-2 kinase led to the discovery of a new family of protein kinases, named α-kinases, whose catalytic domains display no sequence homology to conventional eukaryotic protein kinases. Several mammalian α-kinases have recently been cloned. Two of these α-kinases, named channel-kinases 1 and 2 (ChaK1 and ChaK2) represent a new type of signaling molecules that are protein kinases fused to ion channels.
【 授权许可】
Unknown
【 预 览 】
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